Advances on the role of lncRNA in the formation of keloid

VernacularTitle:长链非编码RNA在瘢痕疙瘩形成机制中的研究进展
Author: Yulong WANG ¹ ; Jingjian HAN ; Xiaodong YAO ; Tianlan ZHAO ; Lijun WU
Author Information

1. 济宁市第一人民医院烧伤整形美容外科，济宁　272000
Keywords: Keloid; Fibroblast; Long noncoding; RNA; Microenvironment; Collagen
From: Chinese Journal of Plastic Surgery 2022;38(8):956-960
CountryChina
Language:Chinese
Abstract: Keloid is defined as special pathological scar invading adjacent healthy skin. The pathogenesis of keloid is not yet fully elucidated. Many factors such as epigenetic inheritance, inflammatory response and mechanical tension have been shown relating to keloid. In recent years, with the rapid progress of epigenetics, more and more studies on long noncoding RNA (lncRNA) have confirmed that it is closely related to keloid formation. Based on the research results of lncRNA, this article reviews its roles in formation and invasion of keloid, by analyzing the relationship between lncRNA and abnormal proliferation of fibrocytes, excessive collagen formation, cell microenvironment, cell migration and other processes.