Novel insight into the role of gut microbiome in colorectal surgery
10.3760/cma.j.cn.441530-20200519-00287
- VernacularTitle:肠道微生态与结直肠外科
- Author:
Ping LAN
1
;
Jinjie WU
;
Zhen HE
Author Information
1. 中山大学附属第六医院结直肠外科，广东省广州 501655
- Keywords:
Colorectal surgery;
Microbiome;
Perioperative period;
Dysbiosis;
Postoperative complications
- From:
Chinese Journal of Gastrointestinal Surgery
2020;23(Z1):21-26
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal surgery is a major therapeutic approach for various colorectal diseases. Surgery and perioperative management, such as fasting, mechanical bowel preparation, and antibiotics use, have an impact on the composition and function of gut microbiome. Abnormal microbiome reconstruction may lead to multiple complications, including infection, gastrointestinal dysfunction, anastomotic leak and disease recurrence. The aim of this review is to elucidate the roles and mechanisms of perioperative interventions of colorectal surgery on gut microbiome, which may provide a novel insight into the microbe-based therapies in the perioperative period of colorectal surgery.
