Relationships between metabolic parameters and islet function in type 2 diabetes complicated with fatty liver disease patients with different duration
10.12025/j.issn.1008-6358.2018.20170709
- VernacularTitle:不同病程2型糖尿病伴脂肪肝患者代谢参数与胰岛功能的相关性分析
- Author:
Zhe GUO
1
;
Xin-Xia CHANG
;
Ming-Feng XIA
;
Hua BIAN
;
Hong-Mei YAN
Author Information
1. 河北省眼科医院内科
- Keywords:
type 2 diabetes mellitus;
liver fat content;
insulin resistance;
the first-phase insulin secretion;
beta cell function
- From:
Chinese Journal of Clinical Medicine
2018;25(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the changes of metabolic parameters and islet function,and to explore the relationships between liver fat content (LFC) and islet function in inpatients of type 2 diabetes mellitus patients with different duration.Methods:Totally 214 diabetic patients and 65 non-diabetes patients from January 2016 to March 2017 were collected.LFC was determined by proton magnetic resonance spectrum analysis (1H-MRS),the first-phase insulin secretion was estimated by arginine test,and insulin secretion index (HOMA-β) and insulin resistance index (HOMA-IR) were assesses by homeostasis model assessment.The changes of the parameters and their relationships were analyzed in each group.Results:Along with the course of disease,the first-phase insulin secretion,HOMA-β and LFC decreased gradually,some parameters such as serum creatinine (SCr),high density lipoprotein cholesterol (HDL-c) and microalbuminuria increased gradually,while there was no significant change in HOMA-IR.Correlation analysis demonstrated that the beta cell function (including the firstphase insulin secretion and HOMA-β) was positively associated with LFC,body mass index (BMI),body weight,waist circumference,hip circumference,serum uric acid (UA),aspartate aminotransferase (AST),triglyceride (TG),waist-hip ratio (WHR,only HOMA-β),alanine aminotransferase (ALT,only the first-phase insulin secretion) and glutamyl transferase (GGT,only the first-phase insulin secretion),all P＜0.05,and was negatively associated with glycosylated hemoglobin (HbA1c),the course (only the first-phase insulin secretion),HDL-c (only the first-phase insulin secretion),all P＜0.01.There were no correlations between beta cell function and the other factors including gender,age,urea nitrogen (BUN),SCr,total cholesterol (TC),low density lipoprotein cholesterol (LDL-c).Stepwise regression analysis showed that there was independently positive correlation between the first-phase insulin secretion and BMI.There were independently positive correlations between HOMA-β and HOMA-IR and BMI in diabetic patients.Conclusions:Along with the course of disease,the degree of insulin resistance is not significantly changed,while the beta cell function and LFC decreased gradually.
