Expression of E3 ubiquitin ligase UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance
10.12025/j.issn.1008-6358.2018.20170935
- VernacularTitle:肝内胆管细胞癌中E3泛素化连接酶UHRF2的表达及临床意义
- Author:
Hai-Ying ZENG
1
;
Rui PENG
;
Xiao-Yong HUANG
;
Xin-Yu ZHANG
;
Xuan YANG
;
Jia-Cheng LU
;
Guo-Ming SHI
;
Aiwu KE
;
Jia-Bin CAI
Author Information
1. 复旦大学附属中山医院病理科
- Keywords:
UHRF2;
intrahepatic cholangiocarcinoma;
prognosis
- From:
Chinese Journal of Clinical Medicine
2018;25(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical significance of ubiquitin-like with PHID and ring finger domains 2 (UHRF2) in intrahepatic cholangiocarcinoma (ICC).Methods:The expression of UHRF2 in 138 ICC was determined by immunohistochemistry,and the relationships between UHRF2 expression with prognosis and clinicopathological features of ICC were analyzed:Results:UHRF2 was highly expressed in ICC compared with paratumorous tissues.Level of UHRF2 was associated with high AFP level (P=0.010),poor tunor differentiation (P=0.026),lymph node metastasis (P=0.001),and advanced TNM stage (P=0.019).Hevated UHRF2 expression was suggested to be associated with poor prognosis and high recurrence rate in ICC patients (P＜ 0.001),and multivariable analysis indicated that UHRF2 was of theprognostic indicators of ICC (P＜0.05).Conclusions:High level of UHRF2 is related to the malignant phenotype of ICC,and can be a prognostic and recurrent indicator of postoperative patients.
