Curative effects of sitagliptin combined with metformin on type 2 diabetic patients complicated with nonalcoholic fatty liver disease
10.12025/j.issn.1008-6358.2017.20170713
- VernacularTitle:西格列汀联合二甲双胍对2型糖尿病合并非酒精性脂肪肝患者的疗效观察
- Author:
Qiong MENG
1
;
Hao HUANG
;
Xiao-Dong FU
Author Information
1. 上海市第三康复医院内科
- Keywords:
type 2 diabetes;
nonalcoholic fatty liver disease;
sitagliptin;
glipizide
- From:
Chinese Journal of Clinical Medicine
2017;24(6):939-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the curative effects of sitagliptin and glipizide on patients of type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease,and to analyze their effects on blood glucose and liver function.Methods:A total of 112 patients of type 2 diabetes mellitus complicated with nonalcoholic fatty liver in the Third Rehabilitation Hospital in Shanghai from June 2015 to April 2017 were randomized into sitagliptin group (n=56) treated with metformin combined with sitagliptin and glipizide group (n=56) treated with metformin combined with glipizide.The efficacy on fatty liver was compared between two groups,the blood glucose,liver function,blood lipid and insulin resistance index (HOMA-IR) were compared between two groups before and after treatment.Results:The total effective rate was 94.6％ (53/56) in sitagliptin group,significantly higher than that in glipizide group (75.0％,42/56,P＜0.05).The blood glucose and blood lipid were significantly improved after treatment in both group,with no significantly difference between two groups.The liver function indexes (AST,ALT,GGT) and HOMA-IR were all significantly improved after treatment in both groups,being significantly better in sitagliptin group compared with those in glipizide group (P＜0.05).The overall adverse reaction rate was 19.6％ (11/56) in sitagliptin group and 17.9％ (10/56) in glipizide group,with no statistical difference.Conclusions:Sitagliptin combined with metformin can improve the therapeutic effect on fatty liver in patients of type 2 diabetes complicated with nonalcoholic fatty liver.Compared with glipizide,sitagliptin can more effectively improve the liver function and HOMA-IR,worthy to be popularized.
