Expressions of arginase-2 and inducible nitric oxide synthase in hepatocellular carcinoma and the relations to angiogenesis
10.12025/j.issn.1008-6358.2017.20170512
- VernacularTitle:肝细胞肝癌组织精氨酸酶2和诱导型一氧化氮合酶的表达及与肿瘤血管形成的相关性
- Author:
Feng XIAO
1
;
Chun-Yan GU
;
Jian-Guo SHAO
;
Zheng QIAN
;
Li-Yan CHEN
;
Yan SUN
Author Information
1. 南通市第三人民医院病理科
- Keywords:
arginase-2;
inducible nitric oxide synthase;
hepatocellular carcinoma;
microvascular density
- From:
Chinese Journal of Clinical Medicine
2017;24(6):912-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expressions of arginase-2 (Arg-2) and inducible nitric oxide synthase (iNOS) protein in hepatocellular carcinoma (HCC) and the relations to angiogenesis.Methods:The expressions of Arg-2 and iNOS in tumor specimens from 158 postoperative patients with HCC were detected by using immunohistochemistry.The endothelial cells were irnmunostained with anti-CD34 antibody.The microvessel density (MVD) was quantified by Image-Pro plus 6.2.1 image analysis software.Results:In 158 HCC patients,the positive rates of Arg-2 and iNOS were 73.4％ (116/158) and 83.5％ (132/116),respectively.The expressions of Arg-2 and iNOS in HCC were positively correlated (r=0.474,P=0.000).The MVD was (283.92± 130.69)/0.702 mm2 in 116 HCC specimens with positive expression of Arg-2,and (129.25±51.00)/0.702 mm2 in 42 HCC specimens with negative expression of Arg-2,and the difference was statistically significant (P=0.000).The MVD was (267±131.49)/0.702 mm2 in 132 HCC specimens with positive expression of iNOS,and (116±41.85)/0.702 mm2 in 26 HCC specimens with negative expression of iNOS,and the difference was statistically significant(P=0.000).Conclusions:The expressions of Arg-2 and iNOS are positively correlated in HCC tissues,which are both related to MVD.These results suggest that Arg-2 and iNOS may be involved in regulating microvascular angiogenesis in HCC.
