Influence factors for maternal and neonatal telomere length
10.12025/j.issn.1008-6358.2017.20170777
- VernacularTitle:孕妇及其新生儿端粒长度的影响因素分析
- Author:
Qiao WENG
1
;
Jiang-Bo DU
;
Fei YU
;
Guang-Fu JIN
;
Hong-Bing SHEN
;
Ya-Li HU
Author Information
1. 南京大学医学院附属鼓楼医院妇产科
- Keywords:
telomere shortening;
pregnant women;
fetal blood;
influencing factors
- From:
Chinese Journal of Clinical Medicine
2017;24(6):884-891
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To comprehensively investigate the environmental factors influencing maternal and neonatal telomere length at birth,and to provide evidences for exploring the role of telomere in pathogenesis and development of diseases.Methods:From March 2015 to February 2016,444 newborns and their mothers in Nanjing Drum Tower Hospital were enrolled.Questionnaire surveys,physical examinations and clinical assessments were conducted in pregnant women,and the maternal peripheral blood samples as well as their matching umbilical venous blood samples were collected.The relative telomere length was measured by quantitative PCR method.The maternal telomere length and neonatal telomere length were compared by paired t test.The telomere length between different subgroups was compared by variance analysis and t test.The correlation between maternal telomere length and neonatal telomere length as well as the correlations of telomere length with other continuous variables were analyzed by using general linear model.Results:The overall telomere length of cord blood was significantly longer than that of maternal blood (0.358 vs 0.309,P＜0.001),but there was no significant correlation between telomere length of maternal blood and telomere length of cord blood (r2 =0.004,P=0.174).There was a significant positive correlation between maternal education level and the telomere length of cord blood (P =0.022).There were no obvious correlations of maternal and neonatal telomere length with gestational age,delivery mode,newborn sex and birth weight.The more dairy intake during pregnancy,the shorter maternal telomere length (P=0.048).There were no significant differences of maternal and neonatal telomere length among different subgroups intaking fruits,vegetables,meat,animal offal,fish,shrimp,bean products,baked and preserved food,folic acid and vitamins.Coffee drinking during pregnancy was significantly associated with shorter neonatal telomere length (P=0.011).Second hand smoke exposure,alcohol consumption and tea drinking during pregnancy were not significantly associated with maternal and neonatal telomere lengths.Longer maternal telomere length was observed in those taking physical exercise during pregnancy (P=0.01),but no significant difference was observed in neonatal telomere length (P=0.187).Conclusions:Various environment exposures such as education level,intake of dairy products,coffee drinking and physical exercise during pregnancy have significant effects on maternal and neonatal telomere length.This study provides valuable clues for further revealing the role of telomere in diseases.
