Effect of levodopa and benserazide hydrochloride on static balance stability of patients with Parkinson disease under different standing positions: digital evaluation methods with wearable device
10.12025/j.issn.1008-6358.2017.20170052
- VernacularTitle:可穿戴设备数字化评估多巴丝肼对不同站姿条件下帕金森病患者平衡稳定性的影响
- Author:
Chang-Qing LI
1
;
Xi WU
;
Lin-Yong SHEN
;
Xiao-Wu HU
;
Jin-Wu QIAN
Author Information
1. 上海大学智能机械与系统研究室
- Keywords:
Parkinson disease;
static posture balance;
wearable device;
levodopa and benserazide hydrochloride
- From:
Chinese Journal of Clinical Medicine
2017;24(6):863-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of levodopa and benserazide hydrochloride on static balance stability patients with of Parkinson disease (PD) by using wearable device.Methods:PD patients with Hoehn & Yahr stage of grade 3 were enrolled and age-matched healthy subjects were selected as control group.The balance stability data under different positions,including natural standing with open eyes,standing on the feet with open eyes and natural standing with close eyes,were recorded by wearable sensor in ON and OFF state of drug.The swing displacements of antero-posterior/medio-lateral (the center of gravity swing parameters) under different standing positions were compared between two groups.Results:Totally 12 PD patients with Hoehn & Yahr stage of grade 3 and 12 healthy subjects were selected.The age,gender,and score of Montreal cognitive assessment (MoCA) were not significantly different between two groups.In control group,the swing displacement under position of natural standing with open eyes was significantly less than that under position of natural standing with close eyes (P＜0.05).In PD group,the swing displacement was not significantly changed in ON and OFF stage of drug.However,under position of natural standing with open eyes,the displacement of antero-posterior swing in PD group was significantly less than that in control group in OFF state of the drug (P＜0.05);under naturally standing state with close eyes,the displacement of medio-lateral swing in PD group was significantly greater than that in control group (P＜0.05).Conclusions:Digital wearable devices can effectively assess the balance stability of PD patients and healthy people;levodopa and benserazide hydrochloride do not improve the balance capacity of PD patients significantly;PD patients may have abnormal integration of visual and somatosensory.
