Autophagy in clinical therapy of tumor: research progress
10.12025/j.issn.1008-6358.2017.20170190
- VernacularTitle:自噬应用于肿瘤治疗的研究进展
- Author:
Si-Lin WU
1
;
Hai-Lin DING
;
Yu-Ying HUANG
;
Ye GU
;
Xiao-Biao ZHANG
Author Information
1. 复旦大学附属中山医院神经外科
- Keywords:
autophagy;
cell death;
tumor;
therapy on tumor;
apoptosis
- From:
Chinese Journal of Clinical Medicine
2017;24(5):797-801
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a self-decomposing process that is used to degrade long-lived proteins or necrotic organelles.It is extremely dependent on lysosomes,widely present in eukaryotic cells and highly conserved.Autophagy can protect the cells themselves and help them resist the adverse environment at a proper level,but excessive autophagy can result in autophagic cell death.In recent years,with the comprehensive research of autophagy,it has been found that autophagy is closely related to the development and progression of most tumors.More drugs associated with autophagy are used for the clinical treatment of tumors,but they have different therapeutic effects on different tumors,so the impact of autophagy-related drugs on normal cells need to be identified through more clinical trials and experimental studies.This paper reviews the roles of autophagy in the occurrence and development of tumors,and recent progress in the treatment of cancer by regulating autophagy through drugs.
