Effect observation of patient-controlled intravenous analgesia using oxycodone combined with sufentanil after cesarean section: a randomized controlled trial
10.12025/j.issn.1008-6358.2017.20161146
- VernacularTitle:羟考酮联合舒芬太尼用于剖宫产术后静脉镇痛的随机对照研究
- Author:
Jing-Jing NIE
1
;
Shao-Qiang HUANG
;
Yu-Qi LIU
Author Information
1. 复旦大学附属妇产科医院麻醉科
- Keywords:
cesarean section;
patient controlled analgesia,;
oxycodone;
sufentanil
- From:
Chinese Journal of Clinical Medicine
2017;24(5):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of patient-controlled intravenous analgesia (PCIA) using oxycodone combined with sufentanil on cesarean section patients.Methods:Sixty elective cesarean section patients were randomly divided into two groups:SF group (sufentanil 100 μg and ramosetron 0.3 mg),OS group (sufentanil 50 μg,oxycodone 50 mg,and ramosetron 0.3 mg).All patients were received combined spinal-epidural anesthesia,and applied with PCIA after surgery.Making 0.9％ sodium chloride solution to 100 mL,continuous dosage 1 mL/h,pulse dosage 2 mL,the time was 10 min.Numerical pain scores of somatalgia at rest(NRS-R) or movment(NRS-M),numerical pain scores of uterine contraction (NRS-U),patient-controlled intravenous analgesia doses,and side effects were assessed at 6 h,12 h and 24 h after the operation.Results:At the time points of 6,12 and 24 h after surgery,the scores of NRSM,NRS-R,and NRS-U in OS group were lower than those in SF group.Times of bolus and accumulated drugs consumption in OS group were less than those in SF group (P＜0.05).The incidence of nausea in SF group was higher than that in OS group (P＜0.05).There was no significant difference in the incidences of vomiting,dizziness,pruritus or respiratory depression between the two groups.Conclusions:Oxycodone combination with sufentanil in patient-controlled intravenous analgesia may be more effective and without increasing side effects compared with sufentanil alone after cesarean section.
