Advances on strategies for promoting osteogenic differentiation of adipose-derived mesenchymal stem cells

VernacularTitle:促进脂肪来源间充质干细胞成骨分化的诱导方法研究进展
Author: Qingyan DU ¹ ; Luosha GU ; Gaofeng ZHAO ; Ke SHI ; Linbo LIU ; Jianwen ZHANG
Author Information

1. 郑州大学第一附属医院整形外科，郑州　450052
Keywords: Adipose tissue; Mesenchymal stem cells; Osteogenic differentiation; Tissue engineering
From: Chinese Journal of Plastic Surgery 2022;38(1):98-103
CountryChina
Language:Chinese
Abstract: Adipose-derived mesenchymal stem cells (ASCs) are pluripotent adult mesenchymal stem cells that are expected to be ideal seed cells for bone tissue engineering(BTE) due to their biosecurity, abundance, and easy access. However, in comparison with bone marrow mesenchymal stem cells, ASCs possess a relatively limited osteogenic capacity and often require further induction. Advances on strategies for promoting osteogenic differentiation of ASCs are reviewed from following aspects: optimization of scaffolds, addition of bioactive factors or drugs, non-coding RNA regulation, and physical stimulation, so as to provide references for the use of ASCs in BTE.