The diagnostic value of fractional exhaled nitric oxide in allergic asthma
10.12025/j.issn.1008-6358.2017.20170361
- VernacularTitle:呼出气一氧化氮水平对变应性哮喘的诊断价值
- Author:
Su-Lan WEI
1
;
Jian WANG
;
Yan MOU
;
Yan-Jie YANG
;
Mei-Ling JIN
;
Lei ZHU
;
Ling YE
Author Information
1. 复旦大学附属中山医院呼吸科
- Keywords:
fractional exhaled nitric oxide;
allergic asthma;
diagnostic value
- From:
Chinese Journal of Clinical Medicine
2017;24(5):710-714
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) in allergic asthma.Methods:A total of 147 cases of asthma patients who were newly diagnosed or non-standardly treated in the Respiratory Department of Zhongshan Hospital Affiliated to Fudan University from August 2015 to September 2016 were enrolled.The patients were divided into allergic asthma group (n =107) and non-allergic asthma group (n =40).Before standardized treatment,FeNO,lung function,and serum total IgE tests were performed.The receiver operating characteristic curve (ROC) was made to evaluate the diagnostic value of FeNO in allergic asthma.Results:The values of FeNO and total serum IgE were significantly higher in allergic asthma group than those in non-allergic asthma group (P＜0.05),but there was no statistical difference between these two groups in FEV1 ％ pred,FEV1/FVC,or FVC％ pred.In allergic asthma group,the FeNO level was positively correlated with serum total IgE (r=0.298,P＜0.001),but had no correlation with FEV1 ％pred,FEV1/FVC,or FVC％pred.There was no correlation between FeNO and serum total IgE,FEV1 ％,FEV1/FVC,or FVC％ in non-allergic asthma group.In allergic asthma group,there was no statistical difference in FeNO levels between positive and negative patients in the bronchial dilation test.The cut-off value of FeNO to differentiate allergic asthma was 40.05 ppb (1 ppb =1 μL/m3) according to the ROC curve (AUC 0.971,sensitivity 96.3％,specificity 85.0％).Conclusions:FeNO is significantly increased in newly diagnosed or non-standard treatment of allergic asthma and has positive correlation with serum total IgE.When the FeNO value is above 40.05 ppb,the diagnosis of allergic asthma is highly likely.
