Analysis of the serum high-sensitivity cardiac troponin T level and its influencing factors in chronic kidney disease patients

VernacularTitle:慢性肾脏病早期患者高敏心肌肌钙蛋白T水平及其影响因素分析
Author: Yuan-Chen LI ¹ ; Zhi-Gang ZHANG ; Ben-Yan ZHU ; Xiao-Ying WANG
Author Information

1. 复旦大学基础医学院病理学系
Keywords: cardiac troponin T; chronic kidney disease; influencing factors
From: Chinese Journal of Clinical Medicine 2017;24(4):620-623
CountryChina
Language:Chinese
Abstract: Objective:To study the influencing factors of serum high-sensitivity cardiac troponin T(hs-cTnT)levels in chronic kidney disease(CKD)patients.Methods:The clinical data of CKD patients treated at a hospital were collected.Fasting blood samples were collected to measure the level of hs-cTnT.Single factor analysis,univariate linear regression analysis and multiple linear regression analysis were carried out to screen the influencing factors of hs-cTnT.Objective:The level of hs-cTnT was detected in 324 CKD patients,and the median level was 0.012 μg/L.In early-stage CKD patients,Cys C,UACR and left ventricular mass index(LVMI)were positively correlated with hs-cTnT level(P<0.05),and the hs-cTnT level increased significantly in CKD patients with hypertension or diabetes.The estimated glomerular filtration rate(eGFR)was negatively correlated with the hs-cTnT level(P=0.003).Conclusions:The elevated levels of hs-cTnT in CKD patients are associated with a variety of factors,so clinicians should make a comprehensive assessment of the causes of elevated hs-cTnT level.