Clinical efficacy of oxycodone hydrochloride in treatment with postoperative analgesia in patients with radical gastrectomy
10.12025/j.issn.1008-6358.2017.20170154
- VernacularTitle:胃癌根治患者术后应用盐酸羟考酮的镇痛效果观察
- Author:
Liu-Fang CHEN
1
;
Xiang XIAO
;
Zhong-Gang CHEN
;
Yun WU
;
You-Tan LIU
Author Information
1. 南方医科大学深圳医院麻醉科
- Keywords:
oxycodone hydrochloride;
gastric cancer;
pain;
analgesia
- From:
Chinese Journal of Clinical Medicine
2017;24(3):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of oxycodone hydrochloride on postoperative analgesic in patients with radical resection of gastric cancer.Methods:Totally 90 cases with gastric cancer resection in hospital April 2014 and 2015 June were selected and divided into observation group (treated with oxycodone hydrochloride for pain) in 45 cases, control group (treated with sufentanil for pain) in 45 cases.The analgesia effect (pain visual analogue score) at different time, morphina supplement dosage, changes of sedation scores and adverse reactions were compared.Results:The patients in the observation group after operation and postoperative analgesic effect of 2 h and 48 h compared with the control group had no significant difference;the patients in the observation group after operation 6 h, 12 h and 24 h analgesic effect was significantly lower than the control group (P<0.05);the patients in the observation group after 48 h in patients with a total of 2 cases of application of intramuscular injection of morphine, 40 mg was significantly lower than the control group of patients (9 cases) and the number of the total dosage of 150 mg (P<0.05);the number of drug automatic pressing in the observation group was significantly lower than the control group (P<0.05);patients in the observation group after the surgery and postoperative 2 h and 48 h score compared with the control group.The Ramsay sedation score in postoperative 6 h, 12 h, 24 h in observation group were significantly higher than control group (P<0.05);Two cases in observation group had nausea and vomiting after 48h of operation, which was lower than the control group of 10 cases (P<0.05).Conclusions:The oxycodone hydrochloride has satisfied effect on analgesia for gastric cancer radical resection with few adverse effect, which is worth of clinical promotion.
