Progress in the mechanism and application of platelet-rich plasma in fat grafting

VernacularTitle:富血小板血浆在自体脂肪移植中的作用机制及应用研究进展
Author: Bin WEI ¹ ; Changchen WANG ; Jincai FAN
Author Information

1. 武警北京市总队医院外一科　100027
Keywords: Adipose tissue; Autografts; Platelet-rich plasma
From: Chinese Journal of Plastic Surgery 2021;37(10):1175-1180
CountryChina
Language:Chinese
Abstract: Autologous fat grafting has been widely used in clinical surgeries in recent years, while the low survival rate of the graft is an important limitation. Platelet-rich plasma (PRP) is one of the strategies to improve the survival rate of the graft. PRP may promote the survival of the graft by stimulating the vascularization of transplanted fat, enhancing the proliferation and differentiation ability of adipose stem cells, and regulating inflammation. Many clinical studies have been carried out using PRP together with autologous fat grafting, revealing that PRP may promote angiogenesis and fat graft retention, but the effectiveness remains controversial. To provide reference and basis for improving the effectiveness of PRP in autologous fat grafting, we introduced the autologous fat grafting and the mechanism of PRP, analyzed clinical trials of PRP combined with autologous fat grafting in this article.