Expression and clinical significance of metadherin in hepatocellular carcinoma

VernacularTitle:肝细胞肝癌组织异黏蛋白的表达变化及临床意义
Author: Kai ZHU ¹ ; Hao ZHAN ; Jian ZHOU ; Jia FAN ; Zhi DAI
Author Information

1. 复旦大学附属中山医院肝脏外科
Keywords: metadherin; hepatocellular carcinoma; neoplasm metastasis; prognosis
From: Chinese Journal of Clinical Medicine 2017;24(3):334-338
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of metadherin (MTDH) in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis.Methods:The expression of MTDH in HCC and adjucent normal tissues was detected.Co-Immunoprecipitation (Co-IP) and mass spectrometry was used to investigate the protein complex involving MTDH.Results:The expression of MTDH was significantly higher in HCC tumors than that in corresponding normal liver tissues, and tumors with microvascular invasion, pathological satellites, poor differentiation, or TNM stage Ⅱ-Ⅲ were prone to exhibit higher MTDH expression (P<0.01).The clinical outcome was poorer in the MTDH high group than that in the MTDH low group in both the 1-, 3-, 5-year overall survival rates (OS) and the 1-, 3-, 5-year cumulative recurrence rates (P<0.05).CO-IP results showed that MTDH can form a complex with PRMT5.Conclusions:MTDH can accurately predict the poor outcome of HCC patients after surgery, and is a great independent prognostic indicator.