Pathogenesis and treatment progress in chronic kidney disease after acute kidney injury
10.12025/j.issn.1008-6358.2017.20160904
- VernacularTitle:急性肾损伤后慢性肾脏病发病机制及其诊治进展
- Author:
Qing KUANG
1
;
Xiao-Qiang DING
;
Yi FANG
Author Information
1. 复旦大学附属中山医院肾内科
- Keywords:
acutkidneinjury;
chronic kidnedisease;
maladaptivrepair
- From:
Chinese Journal of Clinical Medicine
2017;24(2):307-313
- CountryChina
- Language:Chinese
-
Abstract:
Amongst the survivors of an episode of acute kidney injury, there is an increasing understanding of long-term consequences that may include the development of renal tubulointerstitial fibrosis in chronic kidney disease (CKD) and the progression from CKD to end-stage renal disease (ESRD).The underlying mechanism include maladaptive repair of tubular epithelial cells, immune inflammation overactivation, capillary rarefaction, oxidative stress, etc.As the understanding of the mechanism of chronic outcome after acute kidney injury, the related new intervention targets and strategies have appeared in recent years which create a good prospect for human beings to conquer the problem of poor prognosis of acute renal injury.
