Prophylactic efficiency of dexmedetomidine on postoperative nausea and vomiting in high-risk patients: a randomized controlled trial
10.12025/j.issn.1008-6358.2017.20161215
- VernacularTitle:右美托咪定对恶心呕吐高危患者术后恶心呕吐发生影响的随机对照研究
- Author:
Yi ZHOU
1
;
Sheng LAN
;
Yi LIU
;
Li-Hua FAN
;
Pei-Pei ZHOU
Author Information
1. 第二军医大学长海医院麻醉科
- Keywords:
postoperativnausea anvomiting;
dexmedetomidine;
laparoscopic surgery;
postoperativanalgesia
- From:
Chinese Journal of Clinical Medicine
2017;24(2):238-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prophylactic efficiency of dexmedetomidine on postoperative nausea and vomiting (PONV) in highly susceptible patients.Methods:By using randomized and double-blind controlled trial, 100 non-smoking female patients receiving laparoscopic surgery were selected and randomly divided into dexmedetomidine group and control group.The dexmedetomidine group received 0.6 μg/kg dexmedetomidine before induction, and 3 μg/kg dexmedetomidine after surgery.The severity of PONV, the visual analogue scale (VAS)for pain scores, the use of rescued antiemetic and analgesic drugs were assessed for 48 h postoperatively.Results:There were 93 patients completed the study (47 cases in dexmedetomidine group and 46 cases in control group).The number of patients classified as PONV 0 in dexmedetomidine group was significantly more than that in the control group during the time interval 0 to 6 h postoperatively (37 vs 27, P<0.05).The percentage of the usage of antiemetic drugs within 48 hours in dexmedetomidine group was lower than that in control group(25.5% vs 47.8%,P<0.05).During the time intervals 6 to 24 h and 24 to 48 h, the pain scores were significantly lower in dexmedetomidine group compared with control group, 2.9±0.9 vs 3.4±0.7 and 2.7±0.6 vs 3.0±0.7, respectively (P<0.05).Conclusions:Dexmedetomidine used perioperatively might decrease the severity of PONV in early phase postoperatively in highly susceptible patients, and reduce the need for antiemetic drugs and improve the analgesia effects.
