The value of metoclopramide stimulation test in etiological diagnosis of hyperprolactinemia and its influencing factors
10.12025/j.issn.1008-6358.2017.20161216
- VernacularTitle:甲氧氯普胺兴奋试验对高泌乳素血症的病因诊断价值及其影响因素
- Author:
Na YI
1
;
Wen-Ting ZHAO
;
Min HE
;
Ye-Hong YANG
;
Zhao-Yun ZHANG
;
Hong LIU
;
Hong-Ying YE
;
Yi-Ming LI
;
Bin LU
Author Information
1. 复旦大学附属华山医院内分泌科
- Keywords:
metoclopramidstimulation test;
hyperprolactinemia;
prolactinoma
- From:
Chinese Journal of Clinical Medicine
2017;24(2):191-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of metoclopramide stimulation test in etiological diagnosis of hyperprolactinemia, and to analyze its possible influencing factors.Methods:Fifty-three patients with hyperprolactinemia treated in Department of Endocrinology of Huashan Hospital from November 2013 to March 2015 were enrolled.The metoclopramide stimulation test and the other related laboratory tests were performed to analyze the factors affecting test results.Results:In all the 53 hyperprolactinemia patients, 37 patients were diagnosed with prolactinoma.The diagnostic sensitivity of the metoclopramide stimulation test for hyperprolactinemia was 81.08%, the specificity was 68.75%, and the accuracy was 77.36%.The consistency test showed a Kappa value as 0.481 (P<0.05).The result of metoclopramide stimulation test was independently associated with the prolactin level at 0 min (OR=1.035,95%CI 1.011-1.059,P<0.001), according to the multiple Logistic regression analysis.Conclusions:The metoclopramide stimulation test has significant value in the identification of the causes in etiological diagnosis of hyperprolactinemia.However, the result of metoclopramide stimulation test may be affected by the baseline of the prolactin level.
