Recent progress and suggestions about breast implant associated-anaplastic large cell lymphoma
10.3760/cma.j.cn114453-20210706-00288
- VernacularTitle:乳房假体相关间变性大细胞淋巴瘤最新进展及建议
- Author:
Zeming LIU
1
;
Sichao CHEN
;
Liang GUO
Author Information
1. 武汉大学中南医院整形美容科 430071
- Keywords:
Breast implant;
Lymphoma, large-cell, anaplastic
- From:
Chinese Journal of Plastic Surgery
2021;37(8):930-933
- CountryChina
- Language:Chinese
-
Abstract:
BIA-ALCL often occurs 7-10 years after breast reconstruction surgery with breast implants and its incidence is about 23-33 per million. The most common symptoms include breast swelling with seroma, breast mass and lymphadenopathy. It’s assumed that BIA-ALCL is associated with immune response induced by textured breast implants with clonal expansion of local CD30 + T cell, some gene mutations such as JAK1 and STAT3 mutations as well as pathogen infections. Currently, ultrasonography, cytological and immunological tests of exudate as well as biopsy of breast mass are commonly applied for diagnosis. From the perspective of oncology, we propose the following suggestions: (1) We should be alert to the risk of missed diagnosis in the current medical environment, and clinical information is suggested to be collected especially for Asian patients. (2) Due to the low incidence and good prognosis of BIA-ALCL, those who have used textured implants don’t need to be over-worried. (3) It is suggested that researches about manufacturing technology of textured breast implants, JAK-STAT mutations and pathogen infections should be carried out to explore the pathogenic mechanisms of BIA-ALCL, and multi-disciplinary cooperation should be advocated to cope with the diagnosis and treatment of this disease.
