Analysis of relevant risk factors of cerebral white matter lesions in patients with type 2 diabetes
10.12025/j.issn.1008-6358.2017.20160560
- VernacularTitle:2型糖尿病患者脑白质病变相关危险因素分析
- Author:
Li SHENG
1
;
Wen-Jie CAO
;
Xin-Mei HUANG
;
Jiong XU
;
Jun LIU
Author Information
1. 复旦大学附属上海市第五人民医院内分泌科
- Keywords:
type 2 diabetes;
white matter lesions;
mild cognitive impairment
- From:
Chinese Journal of Clinical Medicine
2017;24(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between cerebral white matter lesions (WMLs )and mild cognitive impairment (MCI)in patients with type 2 diabetes mellitus and analyze the related risk factors.Methods:Totally 124 cases of patients with type 2 diabetes were divided into WMLs group and non-WMLs group according to the results of brain magnetic resonance imaging and accepted the cognitive function assessment.General clinical data (height,weight,duration of diabetes,hypertension history)were collected.Biochemical index such as fasting glucose,glycosylated hemoglobin,blood lipids,and renal function were tested and the first morning urine was collected.Correlation analysis of cerebral white matter lesions and MCI was performed and related risk factors were clarified.Results:The proportion of MCI in group with WMLs was higher than that of non-WMLs group (P= 0.027).The statistical significances of age,systolic pressure,diastolic blood pressure,body mass index,fasting blood glucose,high density lipoprotein cholesterol (HDL-C),creatinine,uric acid, glomerular filtration rate and hypertension history were found between two groups (P<0.05).Logistic regression analysis showed that age,creatinine,uric acid,glomerular filtration rate were the independent risk factors of WMLs in patients with type 2 diabetes.Conclusions:WMLs is associated with MCI in patients with type 2 diabetes.The increase of age,the deterioration of the renal damage are independently related with WMLs.
