Expression of RNF38 in lung cancer and its clinical significance

VernacularTitle:肺癌组织环指蛋白RNF38的表达及其临床意义
Author: Ji-Jun LI ¹ ; Chun JIN ; Dian XIONG ; Jia-Hao JIANG ; Jian-Yong DING
Author Information

1. 复旦大学附属中山医院胸外科
Keywords: RNF38; lung cancer; prognosis
From: Chinese Journal of Clinical Medicine 2017;24(1):86-88
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of RNF38 in lung cancer,and its correlationship with clinicopathologic feature and prognosis.Methods:Tissue microarray was used to detect the level of RNF38 in 208 lung cancer patients,then its correlationship with clinicopathologic feature and prognosis was analyzed.Results:RNF38 expression was higher in lung cancer tissues compared with the corresponding adjacent normal lung tissues.High level of RNF38 was related significantly to tumor size (P= 0.0002),tumor stage (P= 0.011),lymph node metastasis (P= 0.00004)and histological type (P= 0.030 ).High level of RNF38 indicates low overall survival rate.Single factor analysis showed that RNF38 expression was related to lung cancer patients'prognosis.Conclusions:The high level of RNF38 could be a new marker in predicting the prognosis of lung cancer.