Therapeutic effect of triamcinolone acetonide acetate transdermal delivery with ultrapulse fractional carbon dioxide laser in the treatment of early hypertrophic scar
10.3760/cma.j.cn114453-20200614-00366
- VernacularTitle:超脉冲二氧化碳点阵激光微孔透皮导入醋酸曲安奈德治疗早期增生性瘢痕的效果观察
- Author:
Mingming LI
1
;
Linbo LIU
;
Hailong WU
;
Zheyuan ZHAO
Author Information
1. 郑州大学附属洛阳中心医院烧伤整形科 471099
- Keywords:
Laser therapy;
Cicatrix;
Laser, gas;
Triamcinolone acetonide;
Combined therapy
- From:
Chinese Journal of Plastic Surgery
2021;37(6):612-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of ultrapulse fractional carbon dioxide laser (UFCL) microporous transdermal triamcinolone acetonide acetate (TAA) in the treatment of early hypertrophic scar.Methods:Ninety patients with early hypertrophic scar in Luoyang Central Hospital Affiliated to Zhengzhou University from March 2016 to March 2019 were included and randomly divided into study group ( n=30), control group A ( n=30) and control group B ( n=30). The control group A was treated with UFCL, the control group B was treated with TAA, and the study group was treated with UFCL combined with TAA. All three groups were treated for 6 months. The effectiveness of the three groups before and 6 months after treatment was compared, the status of hypertrophic scar was evaluated by Vancouver Scar Scale (VSS), the pain degree before and after treatment was evaluated by Visual Analogue Scale (VAS), and the patients’ satisfaction with the treatment was also evaluated. Results:(1) The study group and the control group were effective in the treatment of early hypertrophic scar, and the effective rate of the study group was higher than that of the control group A and the control group B [93.3%(28/30) vs. 70.0%(21/30) and 66.7%(20/30); all P<0.05]. (2) There was no significant difference in the scores of color, thickness, softness and vascular distribution among the three groups before treatment ( P>0.05). After 6 months of treatment, the scores of the three groups were lower than those before treatment ( P<0.05). The scores of study group were lower than those of control group A and control group B respectively( P<0.05). (3) There was no significant difference in VAS scores among the three groups before treatment ( P>0.05). The VAS scores of the three groups after treatment were lower than those before treatment, and the VAS scores in study group were lower than those in control group A and control group B( P<0.05). (4) After 6 months of treatment, the satisfaction rate of study group was higher than that of control group A and control group B ( P<0.05). Conclusions:UFCL microporous transdermal TAA can effectively treat early hypertrophic scar, reduce the VSS score and VAS score of hypertrophic scar, significantly improve the state of scar hyperplasia, and improve the satisfaction rate of patients, which can be widely used in clinic.
