Application of nanofat grafting combined with fractional laser to improve depressed facial scars
10.3760/cma.j.cn114453-20201214-00629
- VernacularTitle:纳米脂肪移植联合CO 2点阵激光治疗面部凹陷性瘢痕的临床效果观察
- Author:
Chaojie JIN
1
;
Leilei CHEN
;
Zhaoyang SHI
;
Yi YAO
;
Chen WANG
;
Mengwen ZHANG
;
Huan QIAN
Author Information
1. 浙江大学医学院附属第二医院余杭院区(杭州市余杭区第一人民医院)医疗美容科 310000
- Keywords:
Autograft;
Adipose tissue;
Laser, gas;
Cicatrix;
Nanofat
- From:
Chinese Journal of Plastic Surgery
2021;37(6):606-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of nanofat transplantation combined with CO 2 fractional laser in the treatment of depressed facial scars. Methods:Through a retrospective study, a total of 27 patients with depressed facial scars who got admitted to the plastic surgery department of our hospital from January 2016 to June 2018 were recruited for autologous nanofat transplantation and carbon dioxide fractional laser treatment in combination to treat moderate to severe depressed facial scars. The treatment was carried out as follows: autologous nanofat transplantation was performed, the depressed scar was subcutaneously separated with a 26 G needle, and injected with the autologous nanofat 0.5-1.0 ml/cm 2. After 3 months, the fractional CO 2 laser treatment was performed for a total of 2 times, with an interval of 3 months each time. Before and six months after treatment, patients and surgeons used the Patient and Observer Scar Assessment Scale (POSAS) to evaluate each aspect of scar. The total score for each item was 1-10 points. According to the total POSAS scores of patients and doctors, the degree of improvement of depressed scars was classified and evaluated. Grade 1: invalid, total score reduction ≤ 5 points; grade 2: mildly effective, total score reduction> 5 points and ≤ 10 points; grade 3, effective, total score reduction> 10 points and ≤ 20 points; grade 4, markedly effective, total score reduction> 20 points. Using SPSS 23.0 to do t-test on the data before and after treatment. P<0.05 indicates that the difference is statistically significant. Results:A total of 27 patients were enrolled, including 16 males and 11 females, aged (29.1±7.9) years old. Before and after six months of treatment, the difference between the scores of the patients on all indicators of scar was statistically significant ( P<0.05); the difference between the doctor’s scores was statistically significant ( P<0.01). The total scores of post-total POSAS were (43.7±10.8) and (23.3±3.2) points respectively, the difference was statistically significant ( P<0.01). After six months of treatment, the degree of pain, itching, color, hardness, thickness (depression), elasticity, tension of the depressed scar were significantly improved. Among them, there was 1 case of second-level improvement, 14 cases of third-level improvement, and 12 cases of fourth-level improvement. The total effective rate reached 96.3% (26/27). None of the 27 patients had lumps or cord-like indurations on the filling parts of the face. No embolism, infection, hematoma and other complications occurred after nanofat transplantation in all patients. Skin flushing, burning, edema, pain and other symptoms occurred early after the fractional CO 2 laser treatment, and no hyperpigmentation occurred in the 6-month follow-up after a treatment cycle. Conclusions:The combination of nanofat transplantation technology and carbon dioxide fractional CO 2 laser can produce a significant effect on improving depressed scar, reducing treatment period, rendering a simple operation with few complications.
