Correlationship between preoperative serum HBeAg level and tumor recurrence after radiofrequency ablation in patients with hepatocellular carcinoma
10.12025/j.issn.1008-6358.2016.20160832
- VernacularTitle:原发性肝细胞肝癌射频消融术前血清HBeAg水平与术后复发的相关性
- Author:
Ying-Ting ZHOU
1
;
Xiao-Ying XIE
;
Yu-Hong GAN
;
Ning-Ling GE
;
Yi CHEN
;
Zheng-Gang REN
;
Lan ZHANG
Author Information
1. 复旦大学附属中山医院肝肿瘤内科
- Keywords:
primary hepatocellular carcinoma;
radiofrequency ablation;
HBeAg
- From:
Chinese Journal of Clinical Medicine
2016;23(6):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between preoperative serum HBeAg level and tumor recurrence after radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) .Methods :Clinical data of 391 cases with hepatitis B background of HCC underwent RFA from June 2006 to June 2012 in Zhongshan Hospital ,Fudan University were analyzed retrospectively .According to preoperative levels of HBeAg ,patients were divided into HBeAg positive group (n=112) and HBeAg negative group (n=279) ,with regular followed‐up after operation .The correlationship between HBeAg before RFA and tumor recurrence after RFA was analyzed .Results:The median recurrence‐free survival time (RFS) was (23 .00 ± 1 .99) months in HBeAg positive group ,and the median RFS was (31 .00 ± 3 .49) months in HBeAg negative group (P=0 .002) .Cox proportional hazard regression analysis showed that preoperative AFP level (HR 139 .3 ,95% CI 1 .052‐1 .845 ,P=0 .021) ,serum HBV‐DNA level (HR 1 .402 ,95% CI 1 .013‐1 .939 ,P=0 .041) ,and HBeAg levels (HR 1 .389 , 95% CI 1 .017‐1 .896 , P=0 .039) were the independent risk factors for survival in hepatitis B background HCC patients after RFA .Conclusions :Preoperative serum HBeAg level in patients with primary HCC is closely related to postoperative tumor recurrence .It is an independent risk factor for recurrence of HCC after RFA .
