STAT3 in regulating Th17 differentiation and its relationship with autoimmune hematological diseases

VernacularTitle:STAT3蛋白调节Th 17细胞的分化及其与自身免疫相关性血液疾病的关系
Author: Yang KE ¹ ; Yun-Feng CHENG
Author Information

1. 复旦大学附属中山医院血液科
Keywords: STAT3; Th1 7; autoimmune hematological diseases
From: Chinese Journal of Clinical Medicine 2016;23(5):662-666
CountryChina
Language:Chinese
Abstract: Signal transducers and activators of transcription (STAT ) are mainly involved in cellular signal transduction.Among them,STAT3 is particularly important in promoting the differentiation of Th17 cells.Aberrant activation of STAT3 signaling pathway has been confirmed to be related to a number of autoimmune hematological diseases, such as immune thrombocytopenia (ITP),aplastic anemia (AA),and autoimmune hemolytic anemia (AIHA).This paper has reviewed the relationship between STAT3,Th17 cell differentiation and autoimmune hematological diseases.