The value of automated urine cell DNA quantitative analysis in the differential diagnosis of urinary tract inflammation and bladder cancer
10.12025/j.issn.1008-6358.2016.20160714
- VernacularTitle:自动尿液细胞DNA定量分析对泌尿系统炎症与膀胱癌的鉴别诊断价值
- Author:
Kang WU
1
;
Yan-Ru MAN
;
Wen-Xiao TANG
;
Jing-Long YU
;
Dao-Yin ZHOU
;
An-Mei DENG
;
Yi SUN
;
Hong-Li YAN
Author Information
1. 第二军医大学长海医院实验诊断科
- Keywords:
automated urine cell DNA quantitative analysis;
urinary system inflammation;
bladder cancer
- From:
Chinese Journal of Clinical Medicine
2016;23(5):629-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the application value of urine cell DNA quantitative analysis in the diagnosis of urinary tract tumors.Methods:There were 92 cases of urinary tract inflammation and 39 cases of patients with suspected bladder cancer urine were tested by DNA quantitative determination, conventional cytology test and urine cytology, pathological diagnosis as the gold standard,the value of the three methods in differential diagnosis of urinary tract inflammation and bladder cancer were assessed,the correlationship between urine cell DNA quantitative and tumor types was analyzed. Results:The sensitivity and specificity of urinary DNA ploidy analysis for the diagnosis of bladder cancer were 88.89% and 97.09%,respectively,and the diagnostic accuracy was 94.66%.The sensitivity and specificity of the traditional urine cytology test were 51.85%and 100%,respectively,and the accuracy was 90.07%.The sensitivity and specificity of urine liquid based cytology test in the diagnosis of bladder cancer were 81.48% and 99.04%,respectively,and the diagnostic accuracy was 95.41%.Urine DNA ploidy analysis results >5C cell number and the type of the urinary tract epithelial cancer were associated,high level of urinary tract epithelial cancer group (>5C)cell number was significantly higher than the low level group.Conclusions:The urine DNA quantitative analysis can identify the urinary system inflammation and bladder cancer, which is better than the traditional cytology test.
