Advances in molecular biology and genetic mechanism of craniosynostosis
10.3760/cma.j.cn114453-20200118-00016
- VernacularTitle:颅缝早闭相关分子生物学及遗传机制的研究进展
- Author:
Xinhang DONG
1
;
Xiaolei JIN
Author Information
1. 中国医学科学院北京协和医学院整形外科医院整形十六科 100144
- Keywords:
Craniosynostoses;
Molecular biology;
Genetic variation;
Gene expression regulation
- From:
Chinese Journal of Plastic Surgery
2021;37(4):452-456
- CountryChina
- Language:Chinese
-
Abstract:
Craniosynostosis is a common congenital craniofacial deformity, which seriously affects the normal development of the brain. The related factors and genes are involved in the regulation of the interaction between the dura mater, the skull, and the cranial sutures, which eventually lead to the closure of cranial sutures. Additionally, mutations of related genes will lead to different types of craniosynostosis. Various cytokines that regulate the formation of cranial sutures and the development of osteoblasts, as well as gene mutations related to skull development and closure of cranial sutures, have formed an intricate regulatory network through multi-dimensional interactions. The signaling conduction system of cranial sutures development and closure is damaged by many genetic mutations and interference of intracellular and extracellular signals, which may lead to craniosynostosis. This review focused on the research progress of the key regulatory factors of craniosynostosis.
