Differences of therapeutic efficacy between hemoperfusion associated with hemodialysis and hemodiafiltration
10.12025/j.issn.1008-6358.2016.20160690
- VernacularTitle:血液透析串联血液灌流与血液透析滤过疗效对比
- Author:
Un Cheng-j WANG
1
;
Xiao-Rong BAO
Author Information
1. 复旦大学附属金山医院肾内科
- Keywords:
hemoperfusion combined with hemodialysis (HP+HD );
hemodiafiltration;
macro-molecules;
nutritional status;
quality of life
- From:
Chinese Journal of Clinical Medicine
2016;23(5):613-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of hemoperfusion combined with hemodialysis (HP+HD)and hemodiafiltration (HDF)on the macro-molecules and quality of life and nutritional status of maintenance hemodialysis (MHD) patients.Methods:Sixty patients undergoing MHD were selected and randomly divided into HDF group and (HP+HD) group,with 30 cases in each group.The Leptin,interleukin-6 (IL-6 ),tumor necrosis factor-α(TNF-α)and CRP level were detected.The reduction rates of each molecule were calculated,the nutritional status and quality of life of patients were evaluated,and the differences between two groups were compared.Results:The clearance rates of Leptin,IL-6,and TNF-αin (HP+HD)group were higher than which in HDF group.After 6 months of treatment,the inflammatory markers of IL-6 , TNF-αand CRP in (HP+HD)group were significantly lower than which in HDF group,and the nutritional status and quality of life were better than HDF group as well.Conclusions:HP+HD can effectively reduce the level of macro-molecules, alleviate inflammatory status,improve nutritional status and quality of life.
