Distribution of HPV infection subtypes of high-risk and physical groups in Shanghai
10.12025/j.issn.1008-6358.2016.20160403
- VernacularTitle:上海地区高危人群及体检人群HPV亚型感染分布调查
- Author:
Min-Na SHEN
1
;
Jiong WU
;
Chun-Yan ZHANG
;
Ya-Yun WANG
;
Wei GUO
;
Bai-Shen PAN
;
Bei-Li WANG
Author Information
1. 复旦大学附属中山医院检验科
- Keywords:
human papillomavirus;
genotyping;
cervical lesion;
multiple infection
- From:
Chinese Journal of Clinical Medicine
2016;23(5):597-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the subtype infection status,distribution characteristics of human papilloma virus (HPV),and its correlation with cervical lesions in different groups in Shanghai.Methods:2126 female patients of the gynecology clinic and routine physical examination were detected for HPV genotypes,comparing the distribution of HPV infection and subtypes.Results:HPV overall infection rate,high-risk HPV (HR-HPV)infection rate,single and multiple infection rate in high-risk group,were significantly higher than physical group(P<0.05).HR-HPV,low-risk HPV (LR-HPV)distribution of the two groups were slightly different.HPV infection rate in high-risk group showed bimodal age distribution,with a peak at the<30 age group and the second one at >60 age group,while the <30 age group showed the highest infection rate in physical group.HPV subtypes in each disease group were slightly different.HPV1 6 subtype detection rate increased with the malignancy in cervical lesions,(P<0.05 ).Conclusions:The distribution of HPV infection and pathogenic subtypes of Shanghai was region specific.HPV infection status were different between two risk groups.The latent infection rate of HPV is high in Shanghai population.HPV1 6 subtype has the highest carcinogenic potential in Shanghai.
