Dynamic change of Th17 and Treg cells frequency in nucleoside analogues anti-HBV treatment
10.12025/j.issn.1008-6358.2016.20160286
- VernacularTitle:Th17、Treg细胞频数在核苷类似物抗HBV过程中的动态变化
- Author:
Yong-Qin YU
1
;
Yi LI
;
Tan-Sheng CHEN
;
Qi-Jun LÜ
;
Fang ZHOU
Author Information
1. 东营市胜利油田中心医院感染病科
- Keywords:
chronic hepatitis B;
telbivudine;
Th17 cell;
Treg cell
- From:
Chinese Journal of Clinical Medicine
2016;23(4):480-483
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate dynamic change of T helper 17 cells (Th17) and regulatory T cells(Treg) frequency in hepatitis B e antigen (HBeAg ) positive chronic hepatitis B patients receiving nucleoside analogues treatment . Methods:A total of 30 chronic hepatitis B patients with positive HBeAg were enrolled .All the patients received telbivudine antiviral treatment .The peripheral blood Treg cell frequency ,Th17 cell frequency and Th17/Treg ratio were detected before treatment and at 4th ,8th ,12th ,24th ,36th ,48th weeks after treatment .The total bilirubin in serum (TBIL) ,direct bilirubin in serum (DBIL ) ,alanine transaminase (ALT ) ,aspertate aminotransferase (AST ) ,hepatitis B virus DNA (HBV‐DNA ) and HBeAg level were detected and compared between before and after treatment .The correlations of Treg cell frequency and Th17 cell frequency with the indexes of TBIL ,DBIL ,ALT ,AST ,HBV‐DNA ,HBeAg were analyzed ,respectively .Results:Treg cell frequency was decreased then increased and reached the minimum point at 8th weeks after treatment .Th17 cell frequency decreased during treatment ;and Th17/Treg ratio decreased and was stable at 24th ,36th ,48th week after treatment .The levels of TBIL ,DBIL ,ALT ,AST ,HBV‐DNA and HBeAg were significantly decreased after treatment (P< 0 .05) .Treg cell frequency was positively correlated with HBV‐DNA and HBeAg levels ( P< 0 .05 ) . Th17 cell frequency was positively correlated with TBIL ,DBIL ,ALT and AST levels (P<0 .05) .Conclusions:Treg cell frequency ,Th17 cell frequency and Th17/Treg ratio shows dynamic changes during nucleoside analogues treatment for HBeAg positive chronic hepatitis B patients .They are correlated with liver function indexes after treatment ;they can provide evidence for clinical treatment and prognosis evaluation .
