Expression levels of clusterin and related in flammatory markers in patients with nephrolithiasis
10.12025/j.issn.1008-6358.2016.20160666
- VernacularTitle:肾结石患者丛生蛋白和相关炎症指标的表达
- Author:
Yong-Han PENG
1
;
Min LIU
;
Xiao-Lei SHI
;
Rui CHEN
;
Ling LI
;
Xiao-Feng GAO
;
Tie ZHOU
Author Information
1. 第二军医大学长海医院泌尿外科
- Keywords:
nephrolithiasis;
inflammatory response;
clusterin;
interleukin
- From:
Chinese Journal of Clinical Medicine
2016;23(4):470-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the level of clusterin expression and inflammatory response in patients with nephrolithiasis .Methods:Clinical data ,blood and urine samples of in patients with nephrolithiasis and healthy adults physical examination center were collected from July to September ,2015 in Changhai Hospital ,Second Military Medical University . Fourty‐seven cases with median age of 43 .00 (33 .50‐50 .00) years and 56 cases with median age of 38 .50 (32 .50‐53 .00) years were recruited in the stone and control group ,respectively .ELISA tests were conducted to detect serum and urine clusterin level as well as serum inflammatory markers to make comparison between two groups .Results:There were no significant differences between two groups in age and sex .Serum clusterin level was lower in the stone group than that in the control group (156 .85 [140 .07‐173 .62] ng/mL vs 171 .48 [151 .51‐195 .09] ng/mL , P< 0 .01) ,while urine clusterin level had no significance compared with the control group (52 .76[42 .66‐57 .37] ng/mL vs 53 .37[44 .40‐68 .07]ng/mL) .Serum IL‐1βlevel was higher in the stone group than that in the control group (17 .92 [16 .26‐19 .18] ng/L vs 13 .55 [12 .06‐17 .76] ng/L ,P<0 .01) ,and serum IL‐6 level was also higher in the stone group than that in the control group (53 .22 [46 .04‐71 .46] ng/L vs 46 .58[42 .34‐52 .63] ng/L ,P< 0 .01) .Conclusions:Serum clusterin level decreased and the level of inflammatory response increased in patients with nephrolithiasis .
