The β-catenin and vascular endothelial growth factor expressions and microvessel density in glioma and their correlations
10.12025/j.issn.1008-6358.2016.20160198
- VernacularTitle:脑胶质瘤组织β-连环蛋白、血管内皮生长因子的表达与微血管密度及其相关性研究
- Author:
Jing-Yu ZHANG
1
;
Li-Na ZHANG
;
Yong-Wei SHU
;
Yong-Hui ZHENG
;
Ting-Ting CHU
;
Hong ZHAO
;
Zi-Chao YANG
Author Information
1. 哈尔滨医科大学附属第四医院神经内科
- Keywords:
glioma;
β-catenin;
vascular endothelial growth factor;
microvessel density
- From:
Chinese Journal of Clinical Medicine
2016;23(4):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of β‐catenin ,vascular endothelial growth factor (VEGF) ,and microvessel density in glioma and their correlations .Methods:50 glioma specimens and 40 health control specimens were collected .The gliomas were divided into low grade gliomas (n= 29) and high grade gliomas (n= 21) .The expression ofβ‐catenin in all specimens was detected by immunohistochemistry .The level of VEGF was detected by Western blotting .The expression of CD105 (a surface marker of neovascular endothelial cell) was examined by anti‐CD105 antibody , and the microvessel density was calculated .Results:The positive expression rate of β‐catenin , the level of VEGF and microvessel density in glioma group were significantly higher than that in control group (P<0 .05) .Compared with the low grade gliomas , the three indexes were obviously higher in high grade gliomas (P< 0 .05) .There was a positive correlations between the positive expression rate of β‐catenin ,the level of VEGF ,and microvessel density (P< 0 .05) .Conclusions:The positive expression rate of β‐catenin ,the level of VEGF ,and microvessel density in glioma patients increase obviously ,and those are more significant in the patients with high‐grade glioma .
