Study of the relationship between chromosome abnormality and infertility
10.12025/j.issn.1008-6358.2016.20160618
- VernacularTitle:不孕不育患者染色体核型分析
- Author:
Xin HUANG
1
;
Lei ZHANG
;
Yun-Xiao GUO
;
Yue-Ran ZHAO
Author Information
1. 山东省医学科学院基础医学研究所
- Keywords:
chromosome;
infertility;
karyotype analysis
- From:
Chinese Journal of Clinical Medicine
2016;23(4):422-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between chromosome abnormalities and infertility ,in order to provide evidence for the prevention and treatment of clinical infertility .Methods:Peripheral blood lymphocytes from 743 cases of infertile patients were cultured ,and chromosome karyotype was examined by showing chromosome bands using G analysis combined with C and N analysis .Results:A total of 743 patients were tested in the study ,140 patients detected with abnormal chromosome karyotype ,the detection rate was 18 .84% .Among them ,there were 115 cases of chromosome polymorphism , accounting for 82 .14% of the abnormal karyotype (115/140);9 cases of chromosomal translocation ,accounting for 6 .43% of the abnormal karyotype (9/140);6 cases of Turner syndrome (including 45 ,X ,one case;chimaera ,4 cases;46 ,X ,del (X) (P11) ,one case) ,accounting for 4 .29% of the abnormal karyotype (6/140);3 cases of Klinefelter syndrome ,accounting for 2 .14% of the abnormal karyotype (3/140);2 cases of chromosome insertion ,accounting for 1 .43% of the abnormal karyotype (2/140);2 cases of trisomy 21 syndrome ,accounting for 1 .43% of the abnormal karyotype (2/140);1 case of super‐female syndrome ,accounting for 0 .71% of the abnormal karyotype (1/140);1 case of androgen‐insensitivity syndrome ,accounting for 0 .71% of abnormal karyotype (1/140) .Generally ,one case was first reported in the world ,and 8 cases were first reported in China .Conclusions:Chromosome abnormality is an important factor that leads to infertility .It is important to carry out the analysis of karyotype in infertile patients .
