C-reactive protein rs2808630 T>C in smokers increases non-small cell lung cancer susceptibility
10.12025/j.issn.1008-6358.2016.20151059
- VernacularTitle:C反应蛋白基因rs2808630、吸烟与非小细胞肺癌易感性的相关性
- Author:
Yu-Tao LI
1
;
Yi WANG
;
Yue-Juan XU
;
Yan-Hong ZHANG
;
Shi-Cheng GUO
;
Zhen-Hong ZHAO
;
Qiang LI
;
Da-Ru LU
;
Li JIN
;
Jiu-Cun WANG
;
Cheng QIAN
;
Jun-Jie WU
Author Information
1. 复旦大学现代人类学教育部重点实验室
- Keywords:
C-reactive protein;
rs2808630;
case-control study;
smoking;
non-small cell lung cancer
- From:
Chinese Journal of Clinical Medicine
2016;23(4):415-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between C reactive protein (CRP) rs2808630 and non‐small cell lung cancer (NSCLC) .Methods:CRP rs2808630 Genotyping of 974 NSCLC patients and 1 005 healthy controls from Shanghai and Taizhou of Jiangsu Province based on double ligation and multiplex fluorescence PCR .The effect of rs2808630 on NSCLC susceptibility was analyzed .Results:Compared with TT genotype ,rs2808630 TC genotype significantly increased NSCLC risk (P=0 .034) ,but this association became insignificant after adjusting with age ,gender ,smoking status ,and family history . However ,in the subgroup of smokers ,TC genotype was significantly associated with increased NSCLC risk after adjustment (OR=1 .329 ,95% CI 1 .017‐1 .736 , P=0 .037) .In addition ,TC genotype exhibited a significantly elevated risk of squamous cell carcinoma (OR=1 .383 ,95% CI 1 .023‐1 .870 ,P=0 .035) .Further stratified analysis revealed that TC genotype posed a much higher risk of squamous cell carcinoma among smokers (OR=1 .479 ,95% CI 1 .058‐2 .067 , P=0 .022) .Conclusions:The interaction between rs2808630 T> C and smoking behavior might play an important role in leading to NSCLC especially squamous cell carcinoma .
