Advances in research on ultraviolet-induced skin photoaging and photocarcinogenesis

VernacularTitle:紫外线致皮肤光老化及光癌变机制的研究进展
Author: Jinming SHE ¹ ; Jing CHE ; Congying CHEN ; Liyan LU ; Yang ZHAO ; Ruixin YU ; Lei CUI
Author Information

1. 三峡大学第一临床医学院宜昌市中心人民医院医疗美容科　443003
Keywords: Skinaging; Ultraviolet rays; Extracellular matrix; Reactive oxygen species
From: Chinese Journal of Plastic Surgery 2021;37(2):220-224
CountryChina
Language:Chinese
Abstract: The cumulative exposure of sunlight can accelerate skin aging and canceration. It changes the biological and clinical reactions of the skin, including acute damage(sunburn)and chronic damage(photoaging, photocarcinogenesis, or pigmentation, etc.). This article summarizes the research progress in the effects of ultraviolet rays on skin photoaging and photocarcinogenesis in recent years. The mechanism of photoaging and photocarcinogenesis is the generation of ROS and DNA damage through ultraviolet irradiation, resulting cell damage, inflammation, immunosuppression, extracellular matrix remodeling and changes of angiogenesis. It provides help for the clinical prevention and treatment of photoaging and photocarcinogenesis.