Impact of spasmolytic on polyp and adenoma detection during colonoscopy：a meta-analysis

VernacularTitle:肠道解痉剂对结肠息肉检出率影响的Meta分析
Author: Songxin XU ¹ ; Bin DENG ; Xuefeng GAO ; Dacheng WU ; Yanbing DING
Author Information

1. 225001,江苏省扬州市第一人民医院消化科
Keywords: Antispasmodic agents; Scopolamine; Colonic polyp; Colonic adenoma; Colonoscopy
From: Chinese Journal of Gastrointestinal Surgery 2015;(6):593-596
CountryChina
Language:Chinese
Abstract: Objective To investigate the impact of intestinal spasmolytic on colon polyps and adenoma detection rate during colonoscopy. Methods Literatures related to the effect of intestinal spasmolytic on colon polyp or adenoma detection rate were retrieved from PubMed, Medline, EBSCO, High Wire Press, OVID, EMBASE, and the China National Knowledge Articles, etc. published before July 2014. Unified data were extracted by two researchers independently and organized using Jadad scale to evaluate the quality of the enrolled studies through Review manager 5.2 Meta-analysis software. Results Six articles were enrolled with total 47,509 cases, including 16,867 cases in the scopolamine group and 30,642 cases in the placebo group. Meta analysis showed spasmolytic could increase the detective rate of polyps (OR=1.24, 95% CI:1.19-1.30), adenoma (OR=1.25, 95% CI:1.19-1.30) and high-risk adenoma (OR=1.22, 95% CI:1.16-1.29). Conclusion Using colonoscopy spasmolytic scopolamine can increase the detection rate of colonic polyp and adenoma.