Association of long-term oral low-dose aspirin and survival in colorectal cancer：a meta-analysis
10.3760/cma.j.issn.1671-0274.2015.06.018
- VernacularTitle:结直肠癌患者长期口服低剂量阿司匹林与预后关系的Meta分析
- Author:
Hua YE
1
;
Ping CHEN
;
Wenyu DAI
;
Qi ZHENG
;
Feng WU
Author Information
1. 315010,宁波市第二医院胃肠外科
- Keywords:
Colorectal neoplasms;
Aspirin;
Meta-analysis
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(6):589-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the association between long-term oral low-dose aspirin and overall survival in colorectal cancer patients after diagnosis. Methods The literature databases, such as PubMed, Embase, Cochrane Library, Web of Science, CBM, CNKI, and Wanfang database, were extensively searched to retrieve the comparative studies about the association between low-dose aspirin use after colorectal cancer diagnosis and overall survival published before June 2014. The state 12.0 version software was used for meta-analysis. The quality of these studies was assessed using the Newcastle-Ottawa scale. Results There were eight studies meeting the inclusion criteria for meta-analysis. The total sample size of these studies included 28 103 cases and the score of all the studies was more than 6 points. Meta-analysis of the data using I2 test showed significant heterogeneity (I2=78.2%, P<0.01), therefore, a random effect model was performed. Aspirin use after diagnosis was associated with longer overall survival (HR=0.732, 95% CI:0.613-0.875, P<0.01). There were seven studies with the same design or tumor stage inⅠ-Ⅳ period respectively for sensitivity analysis. The results of studies showed that the sensitivity was low and accurate (HR=0.687, 95% CI: 0.557-0.849, P<0.01; HR=0.682, 95% CI: 0.539-0.864, P<0.01). Conclusion Meta-analysis shows that long-term oral low-dose aspirin after diagnosis of colorectal cancer is identified as a significant prognostic factor.
