Analysis of the effect of different drugs on emergence agitation in children after general anesthesia
- VernacularTitle:不同药物治疗小儿麻醉苏醒期躁动的疗效分析
- Author:
Li NING
1
;
Jian-Er DU
Author Information
1. 上海交通大学医学院附属新华医院麻醉与重症医学科
- Keywords:
ketamine;
fentanyl;
propofol;
emergence agitation
- From:
Chinese Journal of Clinical Medicine
2016;23(3):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of ketamine ,fentanyl and propofol intravenous injection on emergency agitation (EA) in children after anesthesia in pediatric surgery .Methods: Ninety children who suffered from emergence agitation (ASA Ⅰ-Ⅱ) after general anesthesia were selected .They aged 2-7 years old ,weighed 12-31 kg ,and the gender was not limited .They were randomly divided into 3 groups:ketamine group (group K) ,fentanyl group (group F) and propofol group (group P) ,with 30 cases in each group .Intravenous injection of ketamine 1 mg/kg ,fentanyl 1 μg/kg and propofol 1 mg/kg in 3 groups were given to three groups respectively .The degree of EA was evaluated using the Pediatric Anesthesia Emergence Delirium (PAED) Scale .Pain was assessed using the Children’s Hospital of Eastem Ontario Pain Scale (CHEOPS) and sedation was recorded with Ramsay score .The respiratory depression (SpO2 <90% ) ,the children who need breath control by hand ,re-EA and duration of patient stay in post anesthesia care unit (PACU) after treatment were also recorded .Results:PAED and CHEOPs scores significantly decreased and Ramsay scores significantly increased in all groups (P< 0 .05) after treatment .But PAED and CHEOPs values in group K was lower than that in the other two groups (P<0 .05) ,and Ramsay values were higher in group K than those in the other two groups(P<0 .05) .PAED score of group K was lower than that of F group and P group (P<0 .05) ,CHEOP score was lower than P group (P<0 .05) ,and Ramsay sedation score was higher than F group and P group (P< 0 .05) .The percent of respiratory depression ,re-EA and duration of patient stay in PACU was lower in group K than in the other two groups after treatment .Conclusions:1 mg/kg ketamine can safely and effectively treat the occurrence of EA in children after general anesthesia , and the incidence of adverse reaction is less than fentanyl and propofol .
