Prognostic value of lymph node ratio and N stage in stage colorectal cancer
10.3760/cma.j.issn.1671-0274.2015.06.010
- VernacularTitle:淋巴结转移度及肿瘤N分期对Ⅲ期结直肠癌复发或转移的预测价值
- Author:
Jingqing REN
1
;
Fulong XUE
;
Shaojie LIU
;
Jianwei LIU
;
Chaohui LEI
Author Information
1. 510220,广州市红十字会医院普通外科
- Keywords:
Colorectal neoplasms;
Lymph node ratio;
N stage;
Recurrent;
Metastasis
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(6):553-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the prognostic value of lymph node ratio and N staging in stage Ⅲ colorectal cancer. Methods The clinicopathologic factors and follow-up data of 304 cases with stage Ⅲ colorectal cancer from January 1998 to December 2011 were analyzed retrospectively. Multivariate analysis was performed using Cox proportional hazard regression model in forward stepwise regression. Patients were divided into different subgroups according to the number of lymph nodes sample. Results LNR and N stage were independent risk factors for stage Ⅲ colorectal cancer, the prognostic value of LNR was better than that of N stage [Odds ratio were 1.838(95% CI:1.563~2.161) vs. 1.625 (95% CI:1.392~1.898)]. Subgroup analysis showed that, when the number of lymph nodes sample was less than 13, the prognostic value of LNR was better than that of N stage (Odds ratio were 1.836 vs. 1.639). But when the number of lymph nodes sample was more than 13, they were comparable(Odds ratio were 1.876 vs. 1.853). Conclusions The prognostic value of LNR and N stage were comparable for stage Ⅲ colorectal cancer, but when the number of lymph nodes sample was less than 13, LNR was more valuable.
