Effect of atorvastatin on the expression of fractalkine in the circulation of patients with acute coronary syndrome
- VernacularTitle:阿托伐他汀对急性冠脉综合征患者循环中f ractalkine表达的影响
- Author:
Kang YAO
1
;
Hai-Bo LIU
;
Shu-Ning ZHANG
;
Xiao-Wu HONG
;
Hao LU
;
Ju-Ying QIAN
;
Jun-Bo GE
Author Information
1. 复旦大学附属中山医院心内科
- Keywords:
acute coronary syndrome;
atorvastatin;
fractalkine;
inflammation immunity
- From:
Chinese Journal of Clinical Medicine
2016;23(3):269-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of atorvastatin on the expression of soluble fractalkine in the circulation of patients with acute coronary syndrome .Methods:40 patients with acute coronary syndrome (ACS ) confirmed by coronary angiography were selected ,including 20 patients with acute myocardial infarction (AMI group) and20 patients with unstable angina pectoris (UAP group) .Another 20 hyperlipidemia patients with negative coronary angiography were selected as the control group .All three groups were given atorvastatin 20 mg per time ,one time per day for 3 months .Fractalkine levels in elbow vein blood were detected before and after treatment by ELISA method . CX3CR1 expression in peripheral blood mononuclear cells (PBMC) was examined by flow cytometry .Results:On admission ,fractalkine levels in the circulation of AMI group ([1047 ± 348 .9] pg/mL) and UAP Group ([777 .2 ± 324 .4] pg/mL) were significantly higher than that of the control group ([485 .1 ± 26 .09] pg /mL , P< 0 .001 , P= 0 .004);CX3CR1 expression rates of CD14+ monocytes in the circulation of AMI group ([38 .8 ± 15 .4]% ) and UAP group ([29 .2 ± 11 .9]% ) were significantly higher than that of the control group ([15 .2 ± 7 .9]% , P= 0 .009 , P= 0 .03) .After 3 months of atorvastatin treatment ,AMI ([740 .1 ± 269 .9] pg/mL) and UAP ([523 .8 ± 188 .5]pg/mL) fractalkine levels were significantly lower than before treatment (P= 0 .005 , P=0 .01 ) .Conclusions: Atorvastatin can significantly reduce fractalkine expression in the circulation of acute coronary syndrome patients ,and then achievethe immune effect of anti-atherosclerosis inflammation .
