Effects Of Glue Sniffing On Weight Increase Or Central Nervous System Of Young Rat.
- Author:
Heon KIM
;
Sun Min KIM
;
Soo Hun CHO
- Publication Type:Original Article
- Keywords:
glue;
weight;
tail flick;
hot plate;
treadmill;
central nervous system
- MeSH:
Adhesives*;
Adolescent;
Animals;
Brain;
Central Nervous System*;
Exercise Test;
Humans;
Inhalant Abuse*;
Korea;
Male;
Rats*;
Rats, Sprague-Dawley;
Reaction Time;
Rotarod Performance Test;
Social Problems;
Solvents;
Weight Gain
- From:Korean Journal of Preventive Medicine
1993;26(2):222-230
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Industrial glues, known as 'Bonds' in Korea, contain many kinds of organic solvents, and glue sniffing of youths became one of the social problems in Korea. Mixed exposures to solvents by glue sniffing may induce chronic toxicities different from those by exposures to solvents of single component. To test effects of the glue sniffing on weight gain or central nervous system, two groups of 20 male Sprague-Dawley rats were exposed to air(control group) or vapors of the glues to narcotic status(exposed group), and weight check, tail flick test, hot plate test, rotarod treadmill test were done on the 14th, 24th, 36th, 45th, 53rd, 86th, 102nd, 117th, 134th and 151st days after the first exposure. On the 188th day, their brains were excised and examined by a pathologist. Weight gain, controlled against time change, showed significant difference between the groups, but response times in tail flick test, hot plate tests, and rotarod treadmill test didn't. In pathological examination with blind method, no macroscopic or microscopic difference were found between the two groups. These results suggests that organic lesion in central nervous system may not ensue glue sniffing, but, before firm conclusion, more studies in various exposure conditions should be followed.
