Application of gene mutation detection in gastrointestinal stromal tumors
10.3760/cma.j.issn.1671-0274.2015.04.002
- VernacularTitle:基因检测在胃肠间质瘤诊疗中的应用
- Author:
Yachao HOU
1
;
Jingyu DENG
;
Han LIANG
Author Information
1. 300060,天津医科大学肿瘤医院胃部肿瘤科 天津市肿瘤防治重点实验室 国家临床肿瘤医学研究中心
- Keywords:
Gastrointestinal stromal tumors;
c-kit gene;
PDGFR-α gene;
Gene detection
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal stromal tumors (GISTs) are the most common gastrointestinal mesenchymal tumors of the gastrointestinal tract. Most of GISTs are characterized by mutation in the c-kit or PDGFR-α genes. In recent years, detection of gene mutation in GISTs has been widely used. In addition to the contribution to the diagnosis of difficult cases , such detection also has important value in predicting the efficacy of therapeutic drugs targeting, guiding clinical treatment and evaluating the prognosis of patients. In a word, gene mutation detection should be considered as the important standard for exact diagnosis and treatment of GISTs.
