Significance of Phosphorylated Alpha B-Crystallin (Ser59) in Hepatocellular Carcinoma Tissues
- VernacularTitle:Alpha B-crystallin 蛋白 Ser59磷酸化在肝细胞肝癌中的意义
- Author:
H UA NG Xiaoyong
1
;
Aiwu KE
;
Guoming SHI
;
Jian ZHOU
Author Information
1. 复旦大学附属中山医院肝外科
- Keywords:
Phosphorylated alpha B-crystallin;
Hepatocellular carcinoma;
Prognosis
- From:
Chinese Journal of Clinical Medicine
2015;(6):734-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the expression of phosphorylated alpha B-crystallin in hepatocellular carcinoma(HCC) tissues and its significance .Methods : The expression level of phosphorylated alpha B-crystallin in HCC tissues from 403 cases was detected by immunohistochemical staining ,and its correlation with HCC clinicopathologic features and prognosis was analyzed .Results : The expression level of phosphorylate alpha B-crystallin (Ser 59 ) was correlated with tumor size ,tumor encapsulation ,vascular invasion and tissue differentiation ( P < 0 .05 or 0 .01) . However ,it was not correlated with age , gender ,HBsAg ,liver cirrhosis .Multivariate analysis showed that the expression level of phosphorylated alpha B-crystallin (Ser 59 ) was an independent factor for prognosis .Conclusions : The expression level of phosphorylated alpha B-crystallin (Ser 59 ) is correlated with the malignant phenotype and poor prognosis of HCC .
