Diagnostic value of 18F-fluorodexyglucose positron emission tomography combined with contrast enhanced computed tomography in colorectal cancer liver metastasis
10.3760/cma.j.issn.1671-0274.2015.03.009
- VernacularTitle:18氟-脱氧葡萄糖正电子发射计算机断层成像联合同机增强CT对结直肠癌肝转移的诊断价值
- Author:
Zhanwen ZHANG
1
;
Qinghu LYU
;
Feini CHEN
;
Siqin LIAO
;
Jie ZHANG
;
Rui HU
;
Ping HU
Author Information
1. 中山大学附属第六医院影像检验中心
- Keywords:
Colorectal neoplasms;
Liver metastases;
Positron emission tomography;
Contrast enhanced computed tomography;
Diagnosis
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(3):238-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the preoperative diagnostic value of 18F-fluorodexyglucose positron emission tomography combined with contrast enhanced computed tomography (18F-FDG PET-ceCT) in patients with colorectal cancer liver metastasis. Methods Clinical and imaging data of 58 patients with suspicious colorectal cancer liver metastasis between April 2010 and March 2013 were retrospectively evaluated. All the patients underwent 18F-FDG PET-ceCT. On the basis of definitive diagnosis, the sensitivity, specificity, accuracy and consistency of routine PET-CT, ceCT and 18F-FDG PET-ceCT were calculated. Results A total of 147 suspicious lesions of colorectal cancer liver metastasis were found in 58 patients. Finally, 125 lesions were confinmed as malignant, of which 58 (46.4%) lesions were less than 1.0 cm. The other 22 lesions were confinmed as benign , of which 17 (77.3%) lesions were less than 1.0 cm. The diagnostic accuracy of routine PET-CT , ceCT and 18F-FDG PET-ceCT in colorectal cancer liver metastasis for the lesions more than 1.0 cm was 100%, 93.1%,100% respectively, and the consistency with final diagnosis was perfect, moderate, and perfect respectively (Κappa value 01.00, 0.408, 1.00). For the lesions less than 1.0 cm, the accuracy was 42.7%, 78.7%, 94.7% respectively, and the consistency with definitive diagnosis was insignificance, fair, and almost perfect respectively (Κappa value -0.005, 0.305, 0.848). The area under curve (AUC) was 0.525 (95% CI: 0.407-0.462) for routine PET-CT, 0.651 (95% CI:0.532-0.757) for ceCT, and 0.924 (95% CI:0.839-0.972) for 18F-FDG PET-ceCT respectively. The AUC of 18F-FDG PET-ceCT was significantly larger than that of routine PET-CT (Z=5.559, P<0.05) or ceCT (Z=4.183, P<0.05). Conclusion 18F-FDG PET-ceCT can improve the diagnostic accuracy for smaller lesions of colorectal cancer liver metastasis.
