The Effect of Epinephrine Combined with Methylprednisolone Sodium Succinate for Injection for Intrahospital Cardiopulmonary Resuscitation
- VernacularTitle:肾上腺素联合甲泼尼龙琥珀酸钠用于心肺复苏
- Author:
Feng ZHANG
1
;
Zijian YANG
;
Jie SHEN
;
Guoping LIU
;
Yuedong TANG
;
Xiaoyong ZHOU
;
Ming LIU
Author Information
1. 复旦大学附属金山医院急诊科
- Keywords:
Cardiopulmonary resuscitation;
Methylprednisolone;
Epinephrine
- From:
Chinese Journal of Clinical Medicine
2015;(5):670-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether the combination therapy of epinephrine and methylprednisolone during intrahospital cardiopulmonary resuscitation (CPR) could increase the rate of restoration of spontaneous circulation (ROSC) and improve the survival rate after CPR .Methods:One hundred patients with cardiac arrest were randomly recruited and allocated into therapy group(n=50) and control group(n=50) .Standard dose of epinephrine and methylprednisolone were applied in therapy group , while standard dose of methylprednisolone was applied in control group .The ROSC rate and post‐discharge survival rate of patients in both groups were observed .Results:The ROSC rate and post‐discharge survival rate in the therapy group were 62 .0% and 14 .0% ,respectively ,while that in the control group were 16 .0% and 4 .0% ,respectively .The differences between the two groups were statistically significant(P<0 .05) .Conclusions:Combination therapy of methylprednisolone and epinephrine during CPR could significantly improve the ROSC rate and post‐discharge survival rate .
