Effect of Adjuvant Radiotherapy Following Local Resection on Early Stage Low Rectal Cancer
- VernacularTitle:早期低位直肠癌局部切除术后辅助放疗的效果
- Author:
Weilin LI
1
;
Wanwei LIU
Author Information
1. 广东省深圳市中医院普外科
- Keywords:
Low rectal cancer;
Local resection;
Radiotherapy;
Urinary function;
Tumor markers
- From:
Chinese Journal of Clinical Medicine
2015;(5):647-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the safety of adjuvant radiotherapy following local resection for early stage low rectal cancer and its effect on patients’ serum CA199 expression ,urinary function ,and survival time .Methods:A total of 120 patients with early stage low rectal cancer were enrolled .By random number table method ,they were divided into the treatment group and the control group ,with 60 patients in each group .Local resection was given for low rectal cancer in two groups . Postoperative radiotherapy was conducted in the treatment group for a period of five weeks . Results: The main adverse reactions in two groups during the treatment were bone marrow suppression ,gastrointestinal reactions ,neurotoxicity ,and there was no statistically significant difference between the two groups .The serum CA199 expression in both groups after treatment was significantly lower than that before treatment (P< 0 .05) .The expression of serum CA199 in the treatment group after treatment was also significantly lower than that in the control group (P< 0 .05) .The urinary function in the treatment group after treatment was significantly superior to that in the control group ,and the difference was statistically significant (P<0 .05) .All patients were followed up till July 2015 .The median survival time [(27 .63 ± 2 .13) months] and the median progression‐free survival [(21 .23 ± 1 .98) months] in the treatment group were significantly higher than those in the control group [(21 .94 ± 2 .89) months and (18 .81 ± 2 .11) months] ,and the differences were statistically significant (P<0 .05) .Conclusions:The adjuvant radiotherapy following local resection is safe for the early stage low rectal cancer .It can reduce the serum CA199 expression ,promote the recovery of urinary function and prolong the survival time of patients .
