Effect of Promyelocytic Leukemia Protein Deficiency on Prognosis of Gastric and Colorectal Cancers
- VernacularTitle:早幼粒细胞白血病蛋白的缺失对胃癌和结直肠癌预后的影响
- Author:
Shengli LIN
1
;
Yizhang CHEN
;
Tuo YI
;
Tiangeng DONG
;
Xinqiang HONG
;
Jianwei HU
;
Zhen ZHANG
;
Weixin NIU
Author Information
1. 复旦大学附属中山医院普外科
- Keywords:
Promyelocytic leukemia protein;
Gastric cancer;
Colorectal cancer;
Epidermal growth factor receptor;
Vascular endothelial grow th factor
- From:
Chinese Journal of Clinical Medicine
2015;(5):637-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relation between promyelocytic leukemia protein (PML) and gastric and colorectal cancers , and explore the relation between PML and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) .Methods:The expression situations of PML ,EGFR ,and VEGF in gastric and colorectal cancer were detected by immunohistochemistry ,and their relations with tumor invasions ,lymph node metastases ,TNM stages and patients’ survival were analyzed .Results:PML was positively expressed in normal tissue adjacent to gastrointestinal cancer .The rate of PML deficiency was 33 .8% (54/160) in gastric cancer tissue ,while it was 38 .1% (64/168) in colorectal cancer tissue .PML deficiency in gastric cancer tissue was positively correlated with gastric wall invasion (P<0 .001) ,lymph node metastases (P=0 .018) and TNM stage (P<0 .001) ,and the survival period of patients with positive PML was longer than that of patients with negative PML (52 months vs 39 months , P<0 .001) .Age ,PML deficiency and TNM stage were the independent risk factors of gastric cancer prognosis .PML deficiency in colorectal cancer tissue was positively correlated with TNM stage (P=0 .012) ,and the survival period of patients with positive PML was longer than that of patients with negative PML (53 months vs 44 months , P= 0 .001) .The positive expression of EGFR was positively correlated with colorectal wall invasion (P<0 .001) ,lymph node metastases (P<0 .001) and TNM stage (P<0 .001) .PML deficiency ,TNM stage and EGFR expression were the independent risk factors of colorectal cancer prognosis .PML expression was negatively correlated with EGFR and VEGF expression (P<0 .05) .Conclusions:PML deficiency may promote the progression of gastric and colorectal cancer by up‐regulating the expression of EGFR and VEGF .PML deficiency is correlated with prognosis of gastric and colorectal cancer patients .
