Significance of the Dynamic Changes of NT-proBNP Level in the Diagnosis and Prediction of Long-Term Prognosis of Chronic Obstructive Pulmonary Disease Combined with Pulmonary Heart Disease among Han Chinese in Yunnan District
- VernacularTitle:NT-proBNP动态改变在云南地区汉族慢性阻塞性肺疾病合并肺源性心脏病患者诊断及长期预后判断中的意义
- Author:
Zhengquan WANG
1
;
Lubing DONG
;
Gang LI
;
Wenping LI
;
Shaoxi QIN
Author Information
1. 云南省曲靖市第二人民医院心内科
- Keywords:
Chronic obstructive pulmonary disease;
Pulmonary heart disease;
NT-proBNP
- From:
Chinese Journal of Clinical Medicine
2015;(5):616-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical significance of the level and dynamic changes of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) in the diagnosis and prediction of long‐term prognosis for patients with chronic obstructive pulmonary disease (COPD) combined with pulmonary heart disease among Han Chinese in Yunnan district .Methods:A total of 234 patients with COPD who were treated in The Second People′s Hospital of Qujing in Yunnan province during Jan .2013 and Dec .2013 ,were selected .Among them ,there were 98 patients with COPD combined with pulmonary heart disease ,80 patients with acute exacerbation of COPD ,and 56 patients with stable COPD .The clinical data ,results of blood gas analysis and echocardiography were recorded on admission and the levels of NT‐proBNP were measured .Results:The distances of 6 minute walk test(6MWT) in acute exacerbation of COPD and COPD combined with pulmonary heart disease groups were significantly less than that in stable COPD group(P< 0 .01) .The level of NT‐proBNP in COPD combined with pulmonary heart disease group was significantly higher than those in stable COPD and acute exacerbation of COPD group(P< 0 .01) .Kaplan‐Meier survival analysis showed that there was no significant difference regarding the rate of readmission and death during 12 months between the NT‐proBNP<1 000 pg/mL group and the NT‐proBNP≥1 000 pg/mL group(P>0 .05) .The rate of readmission and death during 12 months in the group with NT‐proBNP level decreasing ratio after treatment ≥30% was significantly higher than that in the group with decreasing ratio < 30% (P< 0 .05) .Conclusions: The detection of NT‐proBNP is of great significance to the early diagnosis of COPD combined with pulmonary heart disease .The dynamic changes of NT‐proBNP levels before and after the treatment are superior to single detection of NT‐proBNP level in predicting readmission rate and mortality risk for patients with COPD combined with pulmonary heart disease .
