Changes of Serum Amyloid A Level and Its Significance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- VernacularTitle:血清淀粉样蛋白A水平在慢性阻塞性肺疾病急性加重期的变化及其意义
- Author:
Xufeng LU
1
;
Haiying ZHOU
;
Zhixiong HU
Author Information
1. 复旦大学附属金山医院呼吸科
- Keywords:
Chronic obstructive pulmonary disease;
Acute exacerbation;
Serum amyloid A
- From:
Chinese Journal of Clinical Medicine
2015;(5):613-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes and clinical significance of serum amyloid A (SAA)level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) .Methods:A total of 140 patients with AECOPD ,80 patients with stable stage COPD and 40 health controls during Jun .2012 and Dec .2013 were collected .The serum levels of SAA ,C‐reactive protein(CRP) ,tumor necrosis factor‐α(TNF‐α) and interleukin‐8 (IL‐8) were measured .Results:The serum levels of SAA ,CRP ,TNF‐α and IL‐8 in all patients with COPD were significantly higher than those in the controls (P<0 .05) .The serum levels of SAA ,CRP ,TNF‐α and IL‐8 in patients with AECOPD were significantly higher than those in patients with stable stage COPD(P<005) .SAA level was significantly correlated with TNF‐α level and IL‐8 level(r=0 .78 , r=0 .69 ,P<0 .01) .Serum CRP level was also significantly correlated with TNF‐αlevel and IL‐8 level(r=0 .68 ,r=0 .62 ,P<0 .01) .The area under ROC curve of SAA (0 .841) was larger than that of CRP (0 .749) ,and the difference was statistically significant(P<0 .05) .Conclusions:SAA could be applied as a new biomarker for AECOPD .Its serum level was correlated with the severity of disease .Early detection of SAA may be conducive to the evaluation of disease situation and the treatment strategy for disease .Thus ,it is worthy of clinical application .
